Antispasmodic Activity of Persea cordata Vell. Mez. (Lauraceae) Fractions on Guinea Pig Ileum Induced by 5-Hydroxytryptamine and Bradykinin
نویسندگان
چکیده
Problem statement: Persea cordata previously demonstrated antispasmodic action against two neurotransmitters. It is important confirm such action against other neurotransmitters. Approach: Present study described the antispasmodic activity of polar (EtOAc; n-BuOH) and non polar (nhexane; dichloromethane) fractions from the bark of Persea cordata, against guinea pig ileum contracted by 5-hydroxytryptamine (5-HT) and bradykinin (BK). Results: The results indicated that hexane and dichloromethane fractions caused the most significant relaxant activity against both neurotransmitters tested. Conclusion: The effects seem to be related to the evidenced presence of steroids and terpenes, but additional studies were in progress to identify the active principles of this plant.
منابع مشابه
Effect of sodium ascorbate on rat uterus and guinea pig atria in vitro.
Sodium ascorbate, an antioxidant, has been reported to have a complex stimulating action on guinea pig ileal longitudinal smooth muscle (3.5-7). Acetylcholine-induced contractions are augmented (3,6) in small concentrations. Larger concentrations inhibit spasmogenic responses induced by acetylcholine, histamine and 5-hydroxytryptamine (2,3,5), potentiate the effect of DMPP on guinea pig ileum b...
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